Oncogenomics : Molecular Approaches to Cancer 2004
內容簡介
Diagnoses termed "cancer" consist of hundreds of different diseases with as many constellations of genetic alterations. Genomic technologies have made it possible to identify all of the tumor-specific mutations, to profile individual tumors at the DNA, RNA, and protein levels, and to test in cellular and animal systems the responses of particular genotypes to particular drugs. Oncogenomics and allied disciplines have identified new targets for genotype-specific treatments and provided strategies to validate these targets and to develop drugs. With the potential need to stratify patients by genotype, clinical testing of targeted drugs has become more complicated while expectations of patients, investors, and funding agencies have become accelerated. Oncogenomics: Molecular Approaches to Cancer offers the first rigorous yet broadly accessible treatment of the impact of genomics on cancer research and care. Clearly written by world-renowned scientists in the field, and edited for overall cohesion, Oncogenomics progresses logically from molecular profiling to model systems, cancer pharmacology, and clinical trials. Oncogenomics
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