內容簡介

The field of bioinformatics is advancing at a remarkable rate. With the development of new analytical techniques that make use of the latest advances in machine learning and data science, today’s biologists are gaining fantastic new insights into the natural world’s most complex systems. These rapidly progressing innovations can, however, be difficult to keep pace with.

The expanded fourth edition of the best-selling Bioinformatics aims to remedy this by providing students and professionals alike with a comprehensive survey of the current field. Revised to reflect recent advances in computational biology, it offers practical instruction on the gathering, analysis, and interpretation of data, as well as explanations of the most powerful algorithms presently used for biological discovery. Bioinformatics, Fourth Edition offers the most readable, up-to-date, and thorough introduction to the field for biologists at all levels, covering both key concepts that have stood the test of time and the new and important developments driving this fast-moving discipline forwards.

This new edition features: 

• New chapters on metabolomics, population genetics, metagenomics and microbial community analysis, and translational bioinformatics
• A thorough treatment of statistical methods as applied to biological data
• Special topic boxes and appendices highlighting experimental strategies and advanced concepts
• Annotated reference lists, comprehensive lists of relevant web resources, and an extensive glossary of commonly used terms in bioinformatics, genomics, and proteomics

Bioinformatics is an indispensable companion for researchers, instructors, and students of all levels in molecular biology and computational biology, as well as investigators involved in genomics, clinical research, proteomics, and related fields.

作者簡介

ANDREAS D. BAXEVANIS, PhD, Director of Computational Biology for the National Institutes of Health's Intramural Research Program and a Senior Scientist leading the Computational Genomics Unit at the NIH's National Human Genome Research Institute, Bethesda, MD, USA.

GARY D. BADER, PhD, Ontario Research Chair in Biomarkers of Disease and Professor at the Donnelly Centre and the Departments of Molecular Genetics and Computer Science at the University of Toronto, Toronto, ON, Canada.

DAVID S. WISHART, PhD, Distinguished University Professor in the Departments of Biological Sciences and Computing Science at the University of Alberta, Edmonton, AB, Canada.

目次

1. Biological Sequence Databases

2. Information Retrieval from Biological Databases

3. Assessing Pairwise Sequence Similarity: BLAST and FASTA

4. Genome Browsers

5. Genome Annotation

6. Predictive Methods Using RNA Sequences

7. Predictive Methods Using Protein Sequences

8. Multiple Sequence Alignments

9. Molecular Evolution and Phylogenetic Analysis

10. Expression Analysis

11. Proteomics and Protein Identification by Mass Spectrometry

12. Protein Structure Prediction and Analysis

13. Biological Networks and Pathways

14. Metabolomics

15. Population Genetics

16. Metagenomics and Microbial Community Analysis

17. Translational Bioinformatics

18. Statistical Methods for Biologists

Appendices
 
Glossary

Index