專業研究用書，無法提供教師樣書
內容簡介
The immune system is a complex network in which different cell types and soluble factors interact to efficiently eliminate various kinds of microorganisms as well as aberrant cell clones. The roots of immunologic investigations reach far into the past. In 430 BC, Thucydides reported that survivors of the plague did not present a second time with similar symptoms. The first report of a successful immu- therapy was made by Edward Jenner in 1798 who found a protective effect of cowpox vaccination against human pox. Since then, much knowledge has been accumulated; today, investigations of the molecular mechanisms of immune regulation are of central research interest. The novel insights into gene polymorphisms and gene regulation gathered from this work has improved our knowledge of individual immune reactions and risk factors in overcoming infections. Strategies to use the immune system for cancer treatment have been propelled by the discovery of divergent immunoregulatory cytokines and the introduction of new gene therapy strategies to modify immune responses. Recently, the discovery of various dendritic cells has focused attention on these cell types as central elements of the immune response and to the possibility of dendritic cell expansion, maturation, and consecutive stimulation with immuno- active tumor-specific peptides. Similarly, methods for ex vivo expansion of various stem cell-derived cell types have led to an improved therapeutic management of various benign and malignant diseases.
目次
Primary immunodeficiencies caused by defects of cytokines and cytokine receptors / V. Wahn
Intracellular detection of T-cell cytokines. Differentiation of TH1 and TH2 cells / U. Banning and D. Korholz
Analysis of cytokine profiles in human skin / J. Krutmann, R. Mang and S. Grether-Beck
Intracytoplasmic detection of proinflammatory cytokines and chemokines in monocytes by flow cytometry / C. Schultz
Flow-cytometric immune function methodology for human peripheral blood dendritic cells / K. Willmann
Evaluation of the frequency of virus-specific CD8+ T cells by cytokine flow cytometry / B. Hoffmeister [and others]
Detection of common cytokine and colony stimulating factor gene polymorphisms / T. Lehrnbecher and S.J. Chanock
Apoptosis induction by TRAIL / A. Eggert, H. Sieverts and H. Walczak
Angiogenic cytokines. Quantitative and functional analysis / A. Eggert and J.H. Maris
Experimental strategies for combined suicide and immune cancer gene therapy. An overview / C.M. Kramm, T. Niehues and N.G. Rainov
Gene therapy with plasmids encoding cytokine- or cytokine receptor
IgG chimeric proteins / C.A. Piccirillo and G.J. Prud'homme
Interferon-beta gene therapy for the treatment of arthritis / Y. Chernajovsky [and others]
Gene gun-based in vivo gene transfer. Application to DNA vaccination / T. Sakai and K. Himeno
Purification of the eucaryotic heat-shock proteins Hsp70 and gp96 / A. von Bonin, S.H. More and M. Breloer
Genetic engineering of a recombinant fusion protein possessing an antitumor antibody fragment and a TNF-alpha moiety / J. Xiang and J.R. Gordon
Genetic engineering of dendritic cells by adenovirus-mediated TNF-alpha gene transfer / J. Xiang and J. Wu
Retroviral transfer of T-cell receptor genes into human peripheral blood lymphocytes / T.M. Clay and M.I. Nishimura
Gene transfer to articular chondrocytes with recombinant adenovirus / G.D. Palmer [and others]
Gene therapy of X-linked severe combined immunodeficiency / S. Hacein-Bey-Abina, G. de Saint Basile and M. Cavazzana-Calvo
Gene transfer for generation of tumor and leukemia vaccines / D. Dilloo and A. Zibert
Cytokine gene delivery into the central nervous system using intrathecally injected nonreplicative viral vectors / R. Furlan [and others]
In vitro regulation of colony stimulating factor-mediated hematopoiesis in healthy individuals and patients with different types of myeloproliferative disease / T. Vraetz, P.D. Emanuel and C.M. Niemeyer
In vitro generation of dendritic cells from cord blood CD34+ hematopoietic progenitors cells / B. Canque, M. Rosenzwajg and J.C. Gluckman
Generation of transgenic T cells from human CD34+ cord blood cells / B. Verhasselt, E. Naessens and V. Stove
Ex vivo expansion of umbilical cord blood cells on feeder layers / M. Bornhauser
Ex vivo production of cord blood CD34+ derived myeloid precursors after serum-free static culture / S. Querol
Ex vivo expansion of hematopoietic stem cells / B. Albella [and others]
Large-scale ex vivo expansion of human megakaryocytes for clinical use / P. Lefebvre and I. Cohen
Cytokine-mediated expansion of human NOD-SCID-repopulating cells / K. Tsuji, T. Ueda and Y. Ebihara
Differentiation of human antigen-presenting dendritic cells from CD34+ hematopoietic stem cells in vitro / X.S. Ju and M. Zenke
Dendritic cell development from mobilized peripheral blood CD34+ cells / D.M. Lathers, N. Achille and M.R. Young
In vitro maturation of dendritic cells from blood progenitors / L. Matera and A. Galetto
Generation of human type 1- and type 2-polarized dendritic cells from peripheral blood / P. Kalinski [and others]
Preparation of human dendritic cells for tumor vaccination / M.R. Shurin
Generation of leukemic dendritic cells from patients with acute myeloid leukemia / M. Mohty, B. Gaugler and D. Olive
