Cell Cycle Inhibitors in Cancer Therapy: Current Strategies 2003

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Cell Cycle Inhibitors in Cancer Therapy: Current Strategies 2003

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內容簡介

Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.


目次

1 Cdk Inhibitors: Background and Introduction
2 p27, A Prognostic Indicator Reflecting? ..
3 Cell Cycle Control of Transcription at the G1/S Phase Transition
4 Tumor-Suppressor Genes as Diagnostic Tools
5 Regulation of Cell Cycle and Apoptosis
6 CDK Inhibitors as Targets of Chemoprevention Agents
7 Cell Cycle Regulatory Genes as Targets of Retinoids
8 Modulators of Cyclin-Dependent Kinases: A Novel Therapeutic Approach for the Treatment of Neoplastic Diseases
9 Cell Cycle Regulators: Interactions and Their Role in Diagnosis, Prognosis, and Treatment of Cancer
10 Cell Cycle Regulators as Targets of Anticancer Therapy
11 Mammalian CDK Inhibitors as Targets of Ubiquitinization in Cancer
12 Synthetic Oligopeptides as Cancer Cell Cycle Modulators

ISBN-13碼 : 9780896039308
ISBN-10碼 : 0896039307
出版日期 : 2003
書系代碼 : HP020
作者 : Antonio Giordano.Kenneth J. Soprano
開數 : 16開
頁數 : 326
裝訂 : 精裝
印刷 : 黑白
定價 : 4725

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