An Introduction to Human Molecular Genetics: Mechanisms of Inherited Diseases 2/e 2005

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An Introduction to Human Molecular Genetics: Mechanisms of Inherited Diseases 2/e 2005

內容簡介

The Second Edition of this internationally acclaimed text expands its coverage of the molecular genetics of inherited human diseases with the latest research findings and discoveries. Using a unique, systems-based approach, the text offers readers a thorough explanation of the gene discovery process and how defective genes are linked to inherited disease states in major organ and tissue systems. All the latest developments in functional genomics, proteomics, and microarray technology have been thoroughly incorporated into the text.
The first part of the text introduces readers to the fundamentals of cytogenetics and Mendelian genetics. Next, techniques and strategies for gene manipulation, mapping, and isolation are examined. Readers will particularly appreciate the text's exceptionally thorough and clear explanation of genetic mapping. The final part features unique coverage of the molecular genetics of distinct biological systems, covering muscle, neurological, eye, cancer, and mitochondrial disorders. Throughout the text, helpful figures and diagrams illustrate and clarify complex material.
Readers familiar with the first edition will recognize the text's same lucid and engaging style, and will find a wealth of new and expanded material that brings them fully up to date with a current understanding of the field, including:
• New chapters on complex genetic disorders, genomic imprinting, and human population genetics
• Expanded and fully revised section on clinical genetics, covering diagnostic testing, molecular screening, and various treatments
This text is targeted at upper-level undergraduate students, graduate students, and medical students. It is also an excellent reference for researchers and physicians who need a clinically relevant reference for the molecular genetics of inherited human diseases.

作者簡介

Dr. Jack J. Pasternak received his Ph.D. from Indiana University and is now Professor Emeritus at the University of Waterloo. He has authored or co-authored several textbooks, including Molecular Biotechnology: Principles and Applications of Recombinant DNA.

目次

CHAPTER 1 Understanding Human Disease 
CHAPTER 2 The Genetic System: Chromosomes
CHAPTER 3 The Genetic System: Mendel's Laws of Inheritance and Genetic Linkage
CHAPTER 4 The Molecular Biology of the Gene
CHAPTER 5 Recombinant DNA Technology
CHAPTER 6 Genetic and Physical Mapping of the Human Genome
CHAPTER 7 Discovering Human Disease Genes
CHAPTER 8 Bioinformatics: Genomics, Functional Genomics, and Proteomics
CHAPTER 9 Human Population Genetics
CHAPTER 10 Molecular Genetics of Complex Disorders
CHAPTER 11 Genomic Imprinting: An Epigenetic Modification
CHAPTER 12 Molecular Genetics of Mitochondrial Disorders
CHAPTER 13 Molecular Genetics of Muscle Disorders
CHAPTER 14 Molecular Genetics of Neurological Disorders
CHAPTER 15 Molecular Genetics of the Eye
CHAPTER 16 Molecular Genetics of Cancer Syndromes
CHAPTER 17 Counseling, Diagnostic Testing, and Management of Genetic Disorders
Glossary
Index

ISBN-13碼 : 9780471474265
ISBN-10碼 : 0471474266
出版日期 : 2005
版次 : 2
書系代碼 : 20042
作者 : Jack J. Pasternak
開數 : 菊8開
頁數 : 676
裝訂 : 精裝
定價 : NT$1,550.00

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