This book is directed towards undergraduates and beginning graduate students in microbiology, food science and chemical engineering. Those studying pharmacy, biochemistry and general biology will find it of interest. The section on waste disposal will be of interest to civil engineering and public health students and practitioners. For the benefit of those students who may be unfamiliar with the basic biological assumptions underlying industrial microbiology, such as students of chemical and civil engineering, elements of biology and microbiology are introduced. The new elements which have necessitated the shift in paradigm in industrial microbiology such as bioinformatics, genomics, proteomics, site-directed mutation, metabolic engineering, the human genome project and others are also introduced and their relevance to industrial microbiology and biotechnology indicated. As many references as space will permit are included. The various applications of industrial microbiology are covered broadly, and the chapters are grouped to reflect these applications. The emphasis throughout, however, is on the physiological, biochemical principles, and where possible, the genomic principles behind these applications.
Section A Introduction
chapter 1. Introduction: Scope of Biotechnology and Industrial Microbiology
Section B Biological Basis of Productivity in Industrial Microbiology and Biotechnology
chapter 2. Some Microorganisms Commonly Used in Industrial Microbiology and Biotechnology
chapter 3. Aspects of Molecular Biology and Bioinformatics of Relevance in Industrial Microbiology and Biotechnology
chapter 4. Industrial Media and the Nutrition of Industrial Organisms
chapter 5. Biosynthesis of Industrial Microbiology Products
chapter 6. Overproduction of Metabolites of Industrial Microorganisms
chapter 7. Screening for Productive Strains and Strain Improvement in Biotechnological Organisms
chapter 8. The Preservation of the Gene Pool in Industrial Organisms: Culture Collections
Section C Basic Operations in Industrial Fermentations
chapter 9. Fermentors and Fermentor Operation
chapter 10. Extraction of Fermentation Products
chapter 11. Sterility in Industrial Microbiology
Section D Alcohol-based Fermentation Industries
chapter 12. Production of Beer
chapter 13. Production of Wines and Spirits
chapter 14. Production of Vinegar
Section E Use of Whole Cells for Food Related Purposes
chapter 15. Single Cell Protein (SCP)
chapter 16. Yeast Production
chapter 17. Production of Microbial Insecticides
chapter 18. The Manufacture of Rhizobium Inoculants
chapter 19. Production of Fermented Foods
Section F Production of Metabolites as Bulk Chemicals or as Inputs in Other Processes
chapter 20. Production of Organic Acids and Industrial Alcohol
chapter 21. Production of Amino Acids by Fermentation
chapter 22. Biocatalysts: Immobilized Enzymes and Immobilized Cells
chapter 23. Mining Microbiology: Ore Leaching (Bioleaching) by Microorganisms
Section G Production of Commodities of Medical Importance
chapter 24. Production of Antibiotics and Anti-Tumor Agents
chapter 25. Production of Ergot Alkaloids
chapter 26. Microbial Transformation and Steroids and Sterols
chapter 27. Vaccines
chapter 28. Drug Discovery in Microbial Metabolites: The Search for Microbial Products with Bioactive Properties
Section H Waste Disposal
chapter 29. Treatment of Wastes in Industry
