Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies 2006

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Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies 2006

內容簡介

This exciting new book opens a window into the causes of debilitating neurological disorders such as Parkinson’s disease, CJD and Huntington’s disease, and gives indications of the prospects for therapy, based on the understanding of molecular defects involved in these diseases.
Looking at each specific neurological disorder in turn, the book outlines the role of metals in human biology, in particular in the brain and explores tools for testing potential therapeutic strategies. It concludes with an overview of the potential of both chelation and antioxidant therapy and outlines some perspectives for the future.

作者簡介

Professor Robert R. Crichton, Unité de Biochimie, Belgium.
 
Professor Roberta J. Ward, Unité de Biochimie, Belgium.

目次

01. Metals in Brain, Metal Transport, Storage and Homeostasis
 
02. Oxidative Stress and Redox-Active Metal Ions
 
03. Parkinson's Disease
 
04. Alzheimer's Disease
 
05. Huntington's Disease and Polyglutamine Expansion Neurodegenerative Diseases
 
06. Friedreich's Ataxia and Diseases Associated with Expansion of Non-Coding Triplets
 
07. Creutzfeldt-Jakob and Other Prion Diseases
 
08. Amyotrophic Lateral Sclerosis
 
09. Other Neurological Diseases
 
10. Therapeutic Strategies to Combat the Onset and Progression of Neurodegenerative Diseases
 
11. Animal Models of the Various Neurodegenerative Diseases
 
12. Concluding Remarks
 
Index

ISBN-13碼 : 9780470022559
出版日期 : 2006
ISBN-10碼 : 0470022558
書系代碼 : 27071
作者 : Robert R. Crichton.Roberta J. Ward
開數 : 18開
頁數 : 240
裝訂 : 精裝
定價 : NT$1,450.00

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