Analysis of data compiled by the multi-institutional collaborative study groups has expanded our understanding of the natural history of cancer in children. The pediatric oncologist can now tailor therapy to the individual child on the basis of the patient's age, tumor histology, state of disease, and a variety of other prognostic parameters. The steady increases in the long term survival of children with cancer have spawned a new area of cautious optimism.

This book presents all aspects of pediatric neoplastic diseases, covering a broad range of clinical and biological manifestations and treatment. It focuses on the practical needs of the clinicians as well as on the frontiers of clinical and basic research.

During the past few decades, there has been an explosive increase of knowledge in disciplines related to children's cancer. New disease entities, new diagnostic methods, and novel therapeutic modalities have been introduced. These clinical advances are largely based on new insights into.