Taking medication is a common occurrence for many people, whether it is to soothe an aching head, regulate blood sugars, or to treat life threatening conditions, such as HIV or cancer. In the UK alone, over 900 million prescriptions are dispensed every year. Overseeing all of this are pharmacists: experts in medicines and their use.

 

The Integrated Foundations of Pharmacy series supports those who are at the beginning of their journey to become a pharmacist. The reader will begin to understand how a drug molecule is made; the process that turns it into a medicine; the role the pharmacist has when dispensing that medicine; and what happens in the body when it is taken. Most importantly, the series shows how each of these aspects are integrated, reflecting the most up-to-date teaching practices.

 

Pharmaceutical Chemistry provides a wide-ranging overview of organic chemistry as applied to the study and practice of pharmacy. Drugs are simply chemicals, so to fully understand their manufacture, formulation, and the way they work in our bodies, an understanding of organic compounds and their reactions is essential.

Dr. Jill Barber studied Natural Sciences at the University of Cambridge and completed a PhD in Bioorganic Chemistry at the same university in 1980. She then spent five years in some of the oldest universities in Europe, learning Biochemistry, German, and Renaissance Music. She settled in Manchester in 1986, with a permanent position in the School of Pharmacy and Pharmaceutical Sciences. Her research focuses on drugs that inhibit protein synthesis and she teaches chemotherapy and its underlying chemistry and biochemistry. She has published several teaching-related research papers about the factors influencing student success.

 

Dr. Chris Rostron graduated in Pharmacy from Manchester University and completed a PhD in Medicinal Chemistry at Aston University. He gained Chartered Chemist status in 1975. After a period of post-doctoral research he was appointed as a lecturer in Medicinal Chemistry at Liverpool Polytechnic. He is now an Honorary Research Fellow in the School of Pharmacy and Biomolecular Sciences at Liverpool John Moores University. He was a member of the Academic Pharmacy Group Committee of the Royal Pharmaceutical Society of Great Britain and chairman for five years. He is currently chairman of the Academic Pharmacy Forum and deputy chair of the Education Expert Advisory Panel of the Royal Pharmaceutical Society. He is an external examiner in Medicinal Chemistry at a number of schools of pharmacy both in the UK and abroad. In 2008 he was awarded honorary membership of the Royal Pharmaceutical Society of Great Britain for services to pharmacy education.

Machine generated contents note: 

1.The importance of pharmaceutical chemistry / Jill Barber

1.1.Chemical structures and nomenclature

1.2.The human test tube

1.3.More test tubes: plants and microorganisms

1.4.Glass and plastic test tubes

1.5.From test tube to pharmaceutical

2.Organic structure and bonding / Alastair Mann

2.1.What is organic chemistry?

2.2.The shape of molecules

2.3.The electronic configuration of carbon

2.4.The shape of organic molecules

2.5.Intermolecular forces

2.6.Reaction types and the making and breaking of bonds

2.7.The principles of organic reaction mechanisms

3.Stereochemistry and drug action / Adam Todd

3.1.Introduction

3.2.Constitutional isomerism

3.3.Conformational isomerism

3.4.Stereoisomerism

3.5.Protein folding diseases

4.Properties of aliphatic hydrocarbons / Andrew J. Hall

4.1.Nomenclature

4.2.Physical properties of aliphatic hydrocarbons C 7.2.Why is aromatic chemistry important?

7.3.The chemistry of benzene

7.4.The synthesis of drugs

7.5.Aromatic chemistry in the body

8.Inorganic chemistry in pharmacy / Geoff Hall

8.1.Concepts in inorganic chemistry

8.2.Metals: introduction

8.3.Group 1 metals

8.4.Group 2 metals

8.5.Period 4 metals

8.6.Precious metals

8.7.Phosphorus

8.8.Sulfur

9.The chemistry of biologically important macromolecules / Alex White

9.1.Small molecules versus large molecules

9.2.Nucleic acids and nucleosides

9.3.Proteins

9.4.Carbohydrates

9.5.Lipids

10.Origins of drug molecules / Tim Snape

10.1.Drugs, dyes, and cleaning fluid: similarities and differences

10.2.Natural products as drugs and medicines

10.3.Semi-synthetic drugs

10.4.Synthetic drugs

10.5.Genetic engineering and fermentation (biotechnology) for the production of drugs

10.6.The principles of organic synthesis

10.7.Purification methods 11.Introduction to pharmaceutical analysis / Tony Curtis

11.1.Quality control of pharmaceuticals and formulated products

11.2.The electromagnetic spectrum

11.3.Ultraviolet-visible spectrophotometry

11.4.Infrared spectroscopy

11.5.Nuclear magnetic resonance (NMR) spectroscopy

11.6.Mass spectrometry

11.7.Chromatographic methods of analysis

11.8.Gas-liquid chromatography

12.The molecular characteristics of good drugs / Jill Barber

12.1.Rules in chemistry

12.2.The Rule of Five

an empirical rule

12.3.Structure-activity relationships

12.4.Stereochemistry

12.5.Purity

Index