內容簡介

Incorporating the most important advances in the rapidly-evolving field of cancer biology, this book remains the defining course text on its subject. Students, instructors, researchers, and clinicians the world over admire its authoritative content, clear explanations, extensive full-color art program, and pedagogical features that promote a deep conceptual understanding of the science through the lens of fascinating tales of scientific discovery.

作者簡介

Robert A. Weinberg is a founding member of the Whitehead Institute for Biomedical Research. He is the Daniel K. Ludwig Professor for Cancer Research and?Professor in the Massachusetts Institute of Technology (MIT) Department of Biology.?His research is focused on the molecular and cellular mechanisms of cancer pathogenesis.?He was awarded the U.S. National Medal of Science in 1997.

目次

1. The Biology and Genetics of Cells and Organisms
2. The Nature of Cancer
3. Cancer as an Infectious Disease
4. Cellular Oncogenes
5. Growth Factors, Receptors, and Cancer
6. Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer
7. Tumor Suppressor Genes
8. pRB and Control of Cell Cycle Clock
9. p53: Master Guardian and Executioner
10. Eternal Life: Cell Immortalization and Tumorigenesis
11. Multi-step Tumorigenesis
12. Shaping and Characterizing the Cancer Genome
13. Dialogue Replaces Monologue: Heterotypic Interactions and the Biology of Angiogenesis
14. Moving Out: Invasion and Metastasis
15. Crowd Control: Tumor Immunology
16. Cancer Immunotherapy
17. The Rational Treatment of Cancer